Protein Details: Glutamate receptor 1
Protein ID
ICDB_Pro_0485
Protein Name
Glutamate receptor 1
Gene Name
glr-1; C06E1.4
Organism
Caenorhabditis elegans
Length
962 amino acids
AlphaFoldDB
AF-P34299-F1-model_v4.pdb
Function
Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons; promotes omega turns; a movement that frequently follows backwards locomotion or reversals in response to environmental cues while possibly playing an inhibitory role in alternative neurons to inhibit omega turns.
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Command interneurons of the locomotory control circuit (AIB; AVA; AVB; AVD; AVE and PVC) and motor neurons (RMD; RIM; SMD; AVG; PVQ and URY)
DOI ID
10.1038/378078a0; 10.1038/368032a0; 10.1126/science.282.5396.2012; 10.1523/jneurosci.21-05-01510.2001; 10.1016/s0896-6273(02)00749-3; 10.1038/nature02244; 10.1091/mbc.e06-09-0818; 10.1038/emboj.2011.499; 10.1083/jcb.201104141; 10.1016/j.neuron.2013.07.028; 10.1074/jbc.m113.507541; 10.1371/journal.pgen.1006050
RefSeq
NP_498887.2